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KMID : 0371620020170010021
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Journal of Wonkwang Medical Science
2002 Volume.17 No. 1 p.21 ~ p.26
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Possible Predictors associated with Progression of Acute Lacunar Infarction
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Lee Seung-Hoi
Chang Hyuk
Kim Yo-Sik
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Abstract
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Background: If there were reliable predictors related to prognosis of acute stroke, it would be useful to make therapeutic strategies of acute stroke. But predictors and mechanisms involved in aggravation of neurological status were poorly investigated. The purpose of this study is to find out some predictors related to progression of neurological deficits in the early phase of acute lacunar infarction.
Methods: we enrolled first ever lacunar infarction patients who arrived at hospital within 48hours after clinical onset. All patients had neurological examination and were scored with Canadian neurological scale (CNS) on admission and at 3^rd, 7^th day after stroke. We grouped patients into progressive stroke (PS) and non-progressive stroke (NFS) by using CNS score. PS is defined when CNS score decrease more than one point during first 7 days. All patients had laboratory examination and brain MRI. We compared risk factors and MRI findings between PS and NPS.
Results: Seventy-nine patients were fulfilled inclusion criteria. Twenty four percents of patients were PS and 76% were NPS. Patients with diabetes mellitus or low high density lipoprotein (HDL) cholesterol showed more frequent worsening of CNS score in early phase than patients without. PS group had more risk factors than NPS group. Other factors are not related to worsening CNS score of patients with lacunar infarction.
Conclusion: This study suggests that history of DM, low HDL level and number of stroke risk factor can be possible predictors of progressive lacunar infarction.
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KEYWORD
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progressive lacunar infarction, predictors, Canadian neurological scale
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